The word gene was coined in 1909 to denote Mendelian factors of inheritance. In this five part series we will explore the structure and function i.e. expression of genes. We will begin with a look at the historical milestones in our understanding of gene structure and function. For example, in 1953 Watson and Crick described the DNA of genes as being arranged in a double helix. This arrangement explained the replication of DNA and laid the groundwork for understanding the DNA code. In 2003, the human genome (complete set of nuclear DNA in the human) was sequenced. This sequencing raised many questions such as why the number of protein coding genes was much fewer than expected and what was the function of the many non-coding genes.   DNA is packed into the cell nucleus in a specific three- dimensional arrangement. How does this packing arrangement influence the regulation of gene expression? We will look at the structure of the epigenome and how does it function to regulate the temporal and spatial expression of genes. Most genes are found in the cell nucleus, but mitochondria also contain genes. What is their function?  Other topics that will be explored include the genetic underpinnings of evolution and cancer.   The class will consist of lectures followed by questions and discussion.  No preparation time is required.